Paterson's best known work is her 1943 book The God of the Machine, which at that time was the preeminent individualist manifesto.
In Reason, Stephen Cox writes:
The God of the Machine remains a classic of individualist thought. But it is not a pale historical artifact, locked in its time of origin. It is focused on the great continuing issues of civilization, which it confronts with the authority of Paterson's special character and experience.... [Paterson] was not merely a theorist; she had the creative imagination that brings theory to life and challenges the imaginations of others. There was nobody quite like Isabel Paterson, and there is nothing quite like The God of the Machine.